Horses may have experienced more than one of the observed adverse reactions during the study. The most common One 5× male horse developed a mildly elevated BUN and creatinine over the course of the study, prolonged buccal mucosal bleeding time (BMBT), and a dilated pelvis of the right kidney.
Do not exceed 14 days of treatment. For ease of administration, EQUIOXX … Caution: Federal law restricts Clinical chemistry and coagulation abnormalities were seen in several horses in the 0.5 mg/kg (5×) group.
The structural formula is shown below: Equioxx Oral Paste is administered for up to 14 days for the control of pain and inflammation associated with osteoarthritis in horses. Relative bioavailability of the two formulations was determined based on the analysis of plasma drug concentration in 30 horses at specific intervals during a two period crossover study with firocoxib oral paste and a firocoxib tablet.
72 SYRINGE, PLASTIC (SYRINGE) in 1 CARTON. Use as directed by your veterinarian. Not for use in humans. Change in urination habits (frequency or color). Tuesdays with Tony is the official blog of Tony the Clinic Cat at Springhill Equine Veterinary Clinic in Newberry, Florida.
Keep Equioxx and all medications out of the reach of children.
It is important to periodically discuss your horse's response to Equioxx paste. Thank you. Clients should be advised to discontinue NSAID therapy and contact their veterinarian immediately if any of these signs of intolerance are observed. Gross and microscopic lesions of the kidneys consistent with tubulointerstitial nephropathy were seen in all treated groups.
This sheet is provided only as a summary and does not take the place of instructions from your veterinarian.
Two hundred fifty-three client-owned horses of various breeds, ranging in age from 2 to 37 years and weighing from 595 to 1638 lbs, were randomly administered Equioxx or an active control drug in multi-center field studies.
Elevated hepatic enzymes (GGT or AST) were noted in all study groups at one or more time points. Always provide the Client Information Sheet with the prescription.
Consult a physician in case of accidental ingestion by humans. Equioxx is not for use in horses intended for human food consumption.
What are the possible side effects that may occur in my horse during Equioxx, We comply with the HONcode standard for trustworthy health information -, Information for Owner or Person Treating Horse. Clients should be advised to observe for signs of potential drug toxicity and be given a Client Information Sheet with each prescription.
What to tell/ask your veterinarian before giving Equioxx.
Gastric ulcers of the margo plicatus and glandular area were more prevalent in the 2.5X and 7.5X groups, but not seen in the 12.5X group.
Patients at greatest risk for adverse events are those that are dehydrated, on diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction. Drug compatibility should be monitored in patients requiring adjunctive therapy. To deliver the correct dose, round the horse's body weight up to the nearest 50 pound increment (if the body weight is an exact 50 pound increment, do not round up).
One male 5X horse with an elevated GGT value on Day 42 was noted to have tubulointerstitial nephropathy at the time of necropsy. To deliver the correct dose, round your horse's body weight up to the nearest 50 lb increment (if the body weight is an exact 50 lb increment, do not round up).
Equioxx is a non-steroidal, anti-inflammatory drug (NSAID) for the control of pain and inflammation associated with osteoarthritis in horses. We will continue purchasing it. See Information for Owner or Person Treating Horse section of this package insert. In a target animal safety study conducted to support the approval of Equioxx Oral Paste (NADA 141-253), firocoxib was administered orally to healthy adult horses (two male castrates and four females per group) at 0, 0.1, 0.3 and 0.5 mg firocoxib/kg body weight (1, 3 and 5X the recommended dose) for 30 days. Drug compatibility should be monitored in patients requiring adjunctive therapy.
My horse has improved so much by using this product!
Adverse reactions may include erosions and ulcers of the gums, tongue, lips and face, weight loss, colic, diarrhea, or icterus. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function.
All medicines that you are giving or plan to give to your horse, including those you can get without a prescription and any dietary supplements.
In another target animal safety study, firocoxib was administered orally to healthy adult horses (three females, two male castrates and one male per group) at 0, 0.25 mg/kg, 0.75 mg/kg and 1.25 mg/kg (2.5, 7.5 and 12.5× the recommended dose of 0.1 mg/kg) for 92 days. Yes, we do price match please give us a call at 1-800-738-6337 and we would be happy to assist you. Your horse should not be given Equioxx if he/she: Equioxx paste should only be given orally to horses.
for the control of pain Great product for my horse that suffers from Navicular. It's available in a chewable tablet and a paste for easy administration. Equioxx comes in an injectable formulation as well as a paste and chewable tablet. with osteoarthritis in horses.
Equioxx is a veterinary prescription non-steroidal anti-inflammatory drug A target animal safety study was conducted to assess the safety of Equioxx Injection followed by Equioxx Oral Paste in the horse. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you liked this blog, please subscribe below, and share it with … Equioxx Paste comes in an easy-to-use oral syringe with graduated markings that will treat 250 lbs of body weight. The signs of OA you have observed in your horse, such as limping or stiffness. Yellowing of gums, skin, or whites of the eyes (jaundice).
**, *Clinical relevance has not been determined.
Dosage Form: FOR ANIMAL USE ONLY. for Horses (Polysulfated Glycosaminoglycan), Itrafungol Oral Solution for Cats (52 ml). For technical assistance or to report suspected adverse reactions, call 1-877-217-3543.
Simparica (sarolaner) Chewables Tablets for Dogs, Senergy (selamectin) Topical Parasiticide for Dogs & Cats, Seresto Flea & Tick Collar for Cats & Dogs, Advantage II Flea Control for Cats and Kittens, Nutramax Dasuquin Joint Supplement for Dogs & Cats, Banamine Paste - SINGLE Syringe 1500mg (30 gm) (Manufacturer may vary), FluMeglumine 50mg/ml Injectable 100ml (Manufacturer may vary), Optimmune Ophthalmic Ointment for Dogs 3.5 gm, Vetmedin (Pimobendan) Chewable Tablets for Dogs, Adequan i.m. Despite a high rate of plasma protein binding (98%), firocoxib exhibits a large volume of distribution (mean Vd(ss) = 1652 mL/kg).
The terminal elimination half-life (T½) in plasma averages 30-40 hours after IV or oral paste dosing. In target animal safety studies, toxicity was seen at the recommended dose when the duration of treatment exceeded 30 days. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Equioxx (firocoxib) inhibits COX-2 (cyclooxygenase-2), which helps generate chemicals that are responsible for pain and inflammation, while sparing COX-1 (cyclooxygenase-1), which helps maintain normal bodily functions.*. Noticed my 20 yr old mare was getting a little stiff so decided to give this a try and after 2 weeks shes noticeably more comfortable. Appropriate laboratory tests should be conducted to establish hematological and serum biochemical baseline data before and periodically during administration of any NSAID.